ABCC11 ELISA Kit for Human(Homo sapiens) | EIAab.comABCC11 ELISA Kit for Human(Homo sapiens)

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ABCC11 (Gene name),

ATP-binding cassette sub-family C member 11 (Protein name ), ABCCB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCC11(MRP8);

Protein name:

ATP-binding cassette sub-family C member 11;

Alternative:

Multidrug resistance-associated protein 8;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1382

Sequence:

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1250:

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1350:

1382:

GKVVEFDRPE | VLRKKPGSLF | AALMATATSS | LR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00664

UniGene:

Hs.652267

STRING:

9606.ENSP00000349017

KEGG:

hsa:85320

SMR:

Q96J66

String:

Q96J66

MIM:

117800

Uniprot:

Q96J66

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ELISA Kit for Human ATP-binding cassette sub-family C member 11

Cat.:

E9625h

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Manual:

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Packing:

96T

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CLIA Kit for Human ATP-binding cassette sub-family C member 11

Cat.:

U9625h

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Packing:

96T

Polyclonal Antibody for Human ATP-binding cassette sub-family C member 11

Cat.:

P9625Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ATP-binding cassette sub-family C member 11

Protein for Human ATP-binding cassette sub-family C member 11

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12."
Tammur J. , Prades C. , Arnould I. , Rzhetsky A. , Hutchinson A. , Adachi M. , Schuetz J.D. , Swoboda K.J. , Ptacek L.J. , Rosier M. , Dean M. , Allikmets R.
Gene273:89-96(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Testis.
2.

"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12."
Yabuuchi H. , Shimizu H. , Takayanagi S. , Ishikawa T.
Biochem. Biophys. Res. Commun.288:933-939(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Liver.
3.

"MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer."
Bera T.K. , Lee S. , Salvatore G. , Lee B.K. , Pastan I.H.
Mol. Med.7:509-516(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS GLU-317 AND ARG-1344
tissue: Mammary gland.
4.

"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine."
Guo Y. , Kotova E. , Chen Z.S. , Lee K. , Hopper-Borge E. , Belinsky M.G. , Kruh G.D.
J. Biol. Chem.278:29509-29514(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYCLIC NUCLEOTIDE EFFLUX
5.

"Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)."
Chen Z.S. , Guo Y. , Belinsky M.G. , Kotova E. , Kruh G.D.
Mol. Pharmacol.67:545-557(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"A SNP in the ABCC11 gene is the determinant of human earwax type."
Yoshiura K. , Kinoshita A. , Ishida T. , Ninokata A. , Ishikawa T. , Kaname T. , Bannai M. , Tokunaga K. , Sonoda S. , Komaki R. , Ihara M. , Saenko V.A. , Alipov G.K. , Sekine I. , Komatsu K. , Takahashi H. , Nakashima M. , Sosonkina N. , more...
Nat. Genet.38:324-330(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-180;CHARACTERIZATION OF VARIANT ARG-180;FUNCTION IN SECRETION OF EARWAX

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